Platelets play a critical role in tumor progression, formation of metastasis, tumor immunosurveillance, and immunotherapy via a manifold of mechanisms, including coating of tumor cells, the release of soluble factors, e.g. TGF-ß, VEGF, and expression of immunoregulatory molecules like PD-L1, GITRL, CD40L and TACI (18–25). The gene discussed is CD274; the disease is neoplasm.