In the circulating blood, adiponectin exerts its activating effects on insulin sensitization, prevention of cardiovascular disease, diet regulation, and mediation of signal transduction pathways through binding with adiponectin receptors, including AdipoR1 (adiponectin receptor-1), expressed highly in skeletal muscle and liver, AdipoR2 (adiponectin receptor-2), localized to the liver, and T-cadherin, which is abundantly expressed in endothelial cells and smooth muscle cells (127) (Figure 1). Here, ADIPOR1 is linked to cardiovascular disorder.