(123) identified that leptin upregulates MMP-13 by mediating the JAK2/STAT3 signaling pathway, while the MMP family was previously proven to degrade various components of the extracellular matrix (e.g., basement membrane and fibronectin) in mutated cancers (ovarian, breast, etc.)with consequent promotion of tumor metastasis. This evidence concerns the gene LEP and neoplasm.