The dual role of chemerin in cancer development is that high serum chemerin levels may indicate increased survival in patients with tumors such as breast cancer, ovarian cancer, hepatocellular carcinoma (HCC), and adrenocortical carcinoma (ACC), while high chemerin expression suggests poor prognosis in patients with gastric cancer and non-small cell lung cancer (NSCLC) (171). Here, RARRES2 is linked to hepatocellular carcinoma.