ADIPOQ and cancer: (31) to eliminate the anti-cancer cell proliferative effect of adiponectin and markedly boosted tumor growth in mice, and further demonstrated that adiponectin reduced cyclin D1 expression by interfering with GSK-3β phosphorylation to prevent its inactivation and degraded β-catenin to inhibit β-catenin accumulation in cells, ultimately blocking PC growth in the G0–G1 phase.