KISS-1R, the natural receptor for kisspeptin, also called Gpr54, belongs to a family of seven transmembrane G protein-coupled receptors consisting of α, β, and γ subunits of which are highly distributed in the pancreas, placenta, pituitary gland, and spinal cord and similarly closely associated tumor metastasis (164, 165). This evidence concerns the gene KISS1R and neoplasm.