LEP and pachyonychia congenita: (21) identified a significantly increased risk of occurrence of PC in patients followed for more than 10 years (OR = 2.55,95% CI = 1.23, 5.27; P = 0.004) by following up 731 cases of pancreatic adenocarcinoma that occurred between 1986 and 2010, which confirmed that leptin increased concentrations correlated with pancreatic carcinogenesis.