Noteworthy, this result was consistent with the significantly positive enrichment for genes involved in PI3K-AKT-mTOR signaling in stage IV compared to stage III T-LBL samples from our previously published dataset (9) (Supplementary Figure S2G) and with Western Blot results related to the AKT pathway activation in stage IV T-LBL compared to stage III and T-ALL samples (Supplementary Figure S3). This evidence concerns the gene PIK3CA and acute lymphoblastic leukemia.