IL6 and acute lymphoblastic leukemia: Figure 2B shows the ten most differentially expressed proteins between stage IV T-LBL (brown) and T-ALL (orange), which included proteins belonging to the JAK/STATs, AKT/mTOR, FAK/ERK1/2 and cell cycle pathways. When focusing on GEP data from stage IV T-LBL and T-ALL samples (9), gene sets associated with angiogenesis, focal adhesion and IL6-JAK-STAT3 signaling resulted significantly upregulated in stage IV T-LBL compared to T-ALL patients (Supplementary Figures S2D-F).