For example, patient 1 (AML) showed a deletion in 5q (del(5)(q14q33)) in the initial clone, patient 2 (MDS) showed a trisomy 8 as well as a pathogenic variant in DNMT3A in the initial clone, and patient 3 (therapy related myeloid neoplasm) showed a translocation t(12;22) in combination with a pathogenic variant in NF1 in the initial clone (see Figure 2 and Table 1/S1). The gene discussed is NF1; the disease is acute myeloid leukemia.