PITX1 and neoplasm: TCN1 is important in vitamin B12 homeostasis (29), Notch1 protein has diverse roles including differentiation and regulation of normal and cancer cells (34), PITX1 is essential in organ development processes (33), MAPK10 and c-Jun are involved in c-Jun N-terminal kinase 3 which is assumed to act as an inhibitor on tumor cell proliferation (15) and Itga6 is involved in cell division, migration, and invasion (15).