AKT1 and cancer: Overall, our data implicate a strong dependence of cancer cells expressing the active AKT-E17K mutant on their enhanced GSH levels for protection against ROS and cell survival, though the TrX system and ROS-detoxifying enzymes (SOD1, catalase) might still be relevant for the maintenance of antioxidant capacity in TrC1 AKT-E17K cells.