TP53 and cancer: Moreover, GSEA analysis indicated that CSTF2 high expression was also associated with cancer-related pathways, such as Myelocytomatosis (MYC) targets, P53 signaling, the Nod-like receptor signaling pathway, glycolysis, Wnt/beta-catenin, and PI3K/Akt/mTOR signaling, which play an important role in promoting tumorigenesis and the progression of HCC (27–31) (Figures 8C–D).