In summary, Par3 serves as a tumor promoter in radiation-induced retinal carcinoma (74) and ovarian cancer (75) and a tumor suppressor in most other cancer types, including breast cancer (23, 76, 77), thyroid cancer (78), lung cancer (79–81), glioma (82), esophageal cancer (83, 84), endometrioid endometrial carcinoma (85), cervical cancer (86), and pancreatic cancer (87). The gene discussed is PARD3; the disease is esophageal cancer.