BRCA1 and breast carcinoma: We also found that only the exposed group of patients diagnosed with breast cancer before 50 years old (p = 0.00978, Figure 5C) and patients carrying tumors with BRCA1 (p = 0.0138, Figure 5D), BRCA2 (p = 0.0366, Figure 5E), and/or PALB2 (p = 0.00058, Figure 5F) variants had a higher mutational burden; the same was not observed in the unexposed group (Supplementary Figure 2).