Karyotype: 90-92,XXYY,der(4) (15)M-BCR/ABL - negative; KMT2A/AF4 - negative; TEL/AML1 - negative; AML/ETO - negative; m-BCR/ABL - negative; E2A/PBX1 - negative; CBFb-MYH11 - negative; FLT3-ITD. – negative. This evidence concerns the gene RUNX1 and acute myeloid leukemia.