The most highly mutated genes, such as MYC, TERT, FASLG, RIPK1, TNFSF10, TARDBP, and CDKN2A, have been well characterized in liver cancer (15, 48), diffuse large B-cell lymphoma (49), neuroblastoma (50), and kidney renal clear cell carcinoma (51, 52). The gene discussed is TARDBP; the disease is diffuse large B-cell lymphoma.