POU5F1 and metastatic malignant neoplasm in the lymph nodes: Finally, statistical analysis of IHC staining results indicated that the expression level of p53 (Table 2) was negatively associated with patient stages (p = 0.001) and HPV16 (p = 0.047), while the expression level of OCT4 (Table 3) was positively associated with patient stages (p = 0.026), lymph node metastasis (p = 0.025), and HPV16 E6 (p = 0.006), respectively.