Most of the genetic alterations observed in HCC lead to high levels of inhibitors of the proapoptotic BCL-2 family members (i.e., BCL-2, BAX, BAK) and the permeabilization of the mitochondrial membrane with the release of cytochrome c that activates caspases 8 and 3 (6). Here, BCL2 is linked to hepatocellular carcinoma.