In order to determine whether the LINC01134/Nrf2/GPX4 axis has clinical correlation and pathological relationship with the occurrence of HCC, we examined the expression of LINC01134 by FISH, and the expression of GPX4 and Nrf2 via IHC in a group of hepatocellular carcinoma tissues (n = 58). This evidence concerns the gene GPX4 and hepatocellular carcinoma.