FOXM1 and hepatocellular carcinoma: USP39 has been reported to promote the cleavage of forkhead box protein M1 (FoxM1) in hepatoma cells to promote the occurrence and development of HCC (111); USP39 knockdown can also induce apoptosis by targeting FoxM1 shear force on mRNA and promote the growth of hepatoma cell SMMC-7721 in vitro and in vivo (112).