In this article, we introduce that OTUB1 OTUD3 OTUD6B ZRANB1 USP14, USP1, USP10, USP39, USP22, USP9X, USP2, USP7, USP4, USP5, USP29, USP15, USP12, USP16, USP27, USP46, USP8, and UCH37 can affect the malignant degree of HCC through the corresponding mechanism. The gene discussed is OTUD3; the disease is hepatocellular carcinoma.