Here, we introduce the structure and function of “USP14, USP1, USP10, USP39, USP22, USP9X, USP2, USP7, USP4, USP5, USP29, USP15, USP12, USP16, USP27, USP46, and USP8” in the USP family research progress in HCC. The gene discussed is USP8; the disease is hepatocellular carcinoma.