Moreover, we discovered, for the first time, the ferroptosis-inhibiting effect of AURKA and clarified that OP-B plays a ferroptosis-inducing role by regulating the expression of AURKA. With the advance of research on the mechanisms of ferroptosis induction in NSCLC, it will have great potential in the clinical treatment of NSCLC. Here, AURKA is linked to non-small cell lung carcinoma.