In the advanced stage of colorectal carcinogenesis, there was an inverse correlation between miRNA-6807-5p and ZG16 and between miRNA 3064-5p and SH3BGRL3. ZG16 is one of the most significantly downregulated genes in colorectal cancer (CRC) tissues (32, 33). Previous studies showed that reduced expression of ZG16 may play an important role in cancer progression (32, 33). In addition, ZG16 may serve as a potential biomarker for CRC diagnosis and prognosis (33). The gene discussed is ZG16; the disease is medical procedure.