As TNBC patients show different treatment responses and prognosis, individualized treatment and prognostic analysis of TNBC patients could be difficult, especially when the diagnosis and treatment of TNBC patients depends on routine clinical and pathological characteristics (including histological grade, primary tumor size, lymph node metastasis and estrogen receptor/progesterone receptor/HER2 expression). The gene discussed is ESR1; the disease is medical procedure.