Indeed, we observed very strong expression of FOXI1 and FOXI1-driven genes in the FOXI1 expressing HOCT cells as well as moderate expression of FOXI1 and FOXI1-driven genes even in the L1CAM expressing HOCT cells, suggesting that the elevated expressions of FOXI1 and its downstream genes may be responsible for the intercalated cell characteristics in BHD-associated kidney cancer (Figures 4E–4G). The gene discussed is L1CAM; the disease is kidney cancer.