Because the primary lesion and lymph node metastasis of HLRCC-associated kidney cancer were clustered in different clusters, we investigated their differentially expressed genes and found that the expression of SLC17A3—a proximal tubule marker—was lost in the lymph node metastasis (Figure 3C) (Jutabha et al., 2011). Here, SLC17A3 is linked to hereditary leiomyomatosis and renal cell cancer.