Cells from VHL-associated kidney cancers and sporadic clear cell renal cell carcinomas were clustered close to glomerulus/vascular, suggesting that those cancers and glomerulus/vascular might share a portion of their transcriptomic profile, and therefore, those cancers may arise from glomerulus/vascular cells(Chen et al., 2016; Gu et al., 2017). Here, VHL is linked to clear cell renal carcinoma.