AKR1C3 and cancer: We found that aldo-keto reductase family 1 member B10 (AKR1B10), NAD(P)H quinone dehydrogenase 1 (NQO1), and aldo-keto reductase family 1 member C3 (AKR1C3) are highly expressed in HLRCC-associated kidney cancer relative to the other cancer types, all of which have been reported to be highly expressed in HLRCC-associated kidney cancer in association with a dysregulated Kelch-like ECH-associated protein 1 (KEAP1)-nuclear factor erythroid 2-related factor 2 (NRF2) axis (Figure 3A) (Ooi et al., 2011).