Cells from the primary lesion and lymph node metastasis of HLRCC-associated kidney cancer formed an independent cluster distant from nephron cells; however, weak expressions of solute carrier family 17 member 3 (SLC17A3), a marker gene for proximal tubule, suggest that HLRCC-associated kidney cancer may have originated from the proximal tubule. Here, SLC17A3 is linked to kidney cancer.