NLRP3 and melanoma: In this work, the primary melanoma A375 cell lines were cultured in vitro, and different transfection protocols were innovatively used to explore the mechanism of the activation of miR-22 targeting the NLRP3 inflammasome on the viability of human skin malignant melanoma A375 cells, to find the target of skin malignant melanoma targeted drug research and development and provide a sustainable theoretical basis for the search for accurate, efficient, and reliable targeted drugs for the treatment of malignant melanoma.