Notably, numbers of E3 ligase have been discovered to catalyze K63-linked ubiquitination chains, which are involved in activating NF-κB or Akt signaling pathway, acting as tumor promoters and facilitating tumor progression (Ji et al., 2021; Xu et al., 2021; Yu et al., 2021; Zhou et al., 2021; Zhu et al., 2021; He et al., 2022). Here, NFKB1 is linked to neoplasm.