The OUT family DUB TRABID preferentially abolishes Smad ubiquitination regulatory factor 1-induced K29/K33-linked poly-ubiquitin chains from UV radiation resistance associated gene (UVRAG), thereby promoting autophagosome maturation and inhibiting cell proliferation in hepatocellular cancer (Feng et al., 2019). The gene discussed is SMURF1; the disease is hepatocellular carcinoma.