Although the consequence of reduced KCC2 level on the fast GABAA receptor inhibition following TMEV infection is not studied in this present study, an impaired synaptic inhibition during both acute and chronic phases of TMEV-induced epilepsy has been reported in the CA3 region of hippocampus (Smeal et al., 2015) and in the dentate granule cells (our unpublished data). The gene discussed is SLC12A5; the disease is infection.