Additionally, MSCs efficiently migrate and home into the primary tumor and secondary metastasis sites due to the secretion of various chemoattractant molecules in the TME, including interferon (IFN)-γ, tumor necrosis factor-α (TNF-α), interleukin (IL)-6, IL-8, transforming growth factor (TGF)-β, hepatocyte growth factor (HGF), platelet-derived growth factor (PDGF), vascular endothelial growth factor (VEGF), and CXCL12 whose receptors exist on MSCs membrane (Dwyer et al., 2007; Seo et al., 2011; D’souza et al., 2013). This evidence concerns the gene VEGFA and neoplasm.