TFAP2A and Patent ductus arteriosus: This deleted exon 4 is located in the transactivation domain of TFAP2 family protein (http://us.expasy.org/sprot/), together with other variants described in syndromic craniosysnostosis (Timberlake et al., 2019) and syndromic PDA (Mani et al., 2005) depicted in Figure 1E.