However, this gene has never been involved in GI complaints, despite being recently described as one of the regulators of the Endothelin Receptor Type B (EDNRB) expression (Ling and Sauka-Spengler, 2019), a known Hirschsprung disease (HSCR) gene involved in GI development and function (Bondurand et al., 2018). Here, EDNRB is linked to Hirschsprung disease.