In addition, SIRT1 is decreased in the cutaneous tissues of AD mouse model, and its modification provides relief from inflammation symptoms via suppressing the expressions of TSLP, cyclooxygenase-2, macrophage inflammatory protein 2, and C-X-C motif chemokine ligand 13 in vivo (Kwon et al., 2021). Here, TSLP is linked to Alzheimer disease.