SHARPIN and Alzheimer disease: According to the down-regulation of Trim32 and Sharpin in AD patients, similar findings were observed that Trim32-deficient mice present TH2-biased inflammation spontaneously developed in imiquimod-induced psoriatic dermatitis (Liu et al., 2017; Wang et al., 2021), while KCs-specific Sharpin knockout mice developed more severe inflammatory AD lesions compared to normal ones (Sundberg et al., 2020).