Rapamycin proved to balance TH1 and TH2 immune responses via influencing cytokines production and suppressing serum IgE in an AD mouse model (Yang F. et al., 2014a); besides, it could increase the levels of FLG, LOR, and involucrin in vitro (Jia and Zeng, 2020). This evidence concerns the gene IGHE and Alzheimer disease.