AKT1 and Hyperkeratosis: Knock-down or deletion of AKT could decrease the expression of FLG and instigate hyperkeratosis both in vivo and ex vivo (Thrash et al., 2006; O’Shaughnessy et al., 2007; Naeem et al., 2017); the absence of AKT could impede KCs proliferation in HaCaT (Buerger et al., 2017).