Besides, Trim32 activates NF-κB to induce KCs apoptosis and thus upregulates TH17 versus TH2 immunity, which explains the lower expression of Trim32 observed in AD patients (Albor et al., 2006; Liu et al., 2010; Samaka and Basha, 2020). This evidence concerns the gene NFKB1 and Alzheimer disease.