NFKB1 and Alzheimer disease: MAPKs play facilitatory roles in the susceptibility to inflammation, which could activate the TNF-α signaling cascades and energize the NF-κB signaling pathways (Giridharan and Srinivasan, 2018); in turn, inflammatory cytokines could promote MAPK phosphorylation and aggravate the secretion of those mediators in AD development (Hong et al., 2015; Ryu et al., 2015; Noh et al., 2016; Pinto et al., 2018; Naruke et al., 2021; Ogura et al., 2021).