Heat shock proteins 27 (HSP27) can directly bind to AKT and result in increased phosphorylation of AKT and MAPK, which are required for KCs differentiation and epidermis formation (O’Shaughnessy et al., 2007; Jonak et al., 2011); further, elevated HSP27 levels were correlated with increased severity of the AD disease severity (Niiyama et al., 2016). This evidence concerns the gene TBCE and Alzheimer disease.