Reportedly, the deficit of phosphoglucomutase3 (a critical sugar nucleotide in glycosylation precursor synthesis) results in a prolonged inflammation in AD patients with increasing serum IgE elevations (Yang et al., 2014b; Zhang et al., 2014); its knockdown in T cells tends to produce excessive TH17 and TH2 cytokines (Zhang et al., 2014). Here, IGHE is linked to Alzheimer disease.