IL13 and Alzheimer disease: Activated ILC2s (expressing high levels of IL-5 and IL-13) could simultaneously facilitate TH2 differentiation and repress TH1 differentiation (Maggi et al., 2017), and IL-4 performs similar functions in AD pathogenesis (Murphy and Reiner, 2002; Chen et al., 2004; Lazarski et al., 2013).