PINK1 and Parkinson disease: However, CRISPR/Cas9-mediated deletion of the monkey PINK1 gene can completely eliminate the expression of PINK1 to elicit severe neurodegeneration in the non-human primate brain (Yang et al., 2019a), which also suggests that PINK1 point mutations found in patients with PD may partially impair PINK1 function to cause age-dependent neurodegeneration.