PRKN and Parkinson disease: Although PINK1/Parkin knockout mouse models are unable to show typical PD phenotypes, Parkin knockout could increase the vulnerability of dopaminergic neurons to exhaustive exercise via STING, a central regulator of the type I interferon response to cytosolic DNA (Sliter et al., 2018), suggesting that loss of Parkin alone is not sufficient to induce neurodegeneration in mice.