PRKN and Parkinson disease: Intensive research based on GWAS has identified that 5%–10% of individuals suffering from PD show dominant or recessive mutations in specific autophagy-related genes such as LRRK2, VPS35, DNAJC6; PARKIN, ATP13A2/Park9 or PINK1/Park6 (Satake et al., 2009; Simón-Sánchez et al., 2009; Klein and Westenberger, 2012).