Therefore, the inhibition of LRRK2 kinase activity is being explored as a potential therapy (Ding and Ren, 2020) and reducing LRRK2 activity in animal models of PD is reported to minimise SNCA aggregation, neuroinflammation, and dopaminergic neuron loss (Daher et al., 2014) (Daher et al., 2015). This evidence concerns the gene LRRK2 and Parkinson disease.