TFEB and Parkinson disease: Transcription factor EB (TFEB) is a master regulator of lysosomal genes (Sardiello et al., 2009) and modulating TFEB activity is proposed as a therapeutic approach to treat PD pathogenesis (Decressac et al., 2013) and consequently there are a number of TFEB agonists being tested in preclinical trials (Chen et al., 2021).