Furthermore, a lack of RAC1 is associated with insulin resistance in humans and rodents (Sylow et al., 2013; Sylow et al., 2014; Raun et al., 2018) and ELMO2 and RAC1, both regulate the insulin dependent membrane translocation of the glucose transporter 4 (GLUT4) in muscle cells (Sun et al., 2016). The gene discussed is INS; the disease is Insulin resistance.