AP3S1 and cancer: AP3S1 was also observed to be overexpressed in 10 cancers such as BRCA, CHOL, ESCA, HNSC, KIRC, KIRP, LIHC, LUAD, and LUSC by comparing tumors with adjacent normal tissues in the TCGA cohort (Figures 2A–I), with lower expression only in PRAD and KICH (Figures 2J,K).