Li et al. (2012) reported neuroprotective activities of Ex-4 toward SOD1 (G93A) mice, a well characterized animal model of familial ALS; Ex-4 administration via subcutaneous osmotic pump (3.5 pM/kg/min) for 12 weeks attenuated motor neuron death and myelinated nerve fiber loss in the spinal cord of the mutant mice. In contrast, a recent study by (Keerie et al., 2021) showed no significant effects of liraglutide (intraperitoneal injection of 25 or 75 nM/kg/day for 2–6 months) on the disease progression in 2 kinds of ALS model mice, such as SOD1 (G93A) and TDP-43 (Q331K). This evidence concerns the gene SOD1 and amyotrophic lateral sclerosis.