AFDN and cortical cataract: It is possible that lens specific removal of other genes encoding cadherin-complex proteins expressed in the lens fibers such as α-N-catenin, p120-catenin, δ-catenin and/or afadin may also cause age-related cortical cataracts however these experiments have yet to be reported (Jun et al., 2012; Lachke et al., 2012; Lang et al., 2014; Maddala and Rao, 2017).