Aquaporin-0 and Connexin 50 deficient mice also have lens fiber cell adhesive function, but the cataracts that occur in these models are nuclear, present at an early age, and are likely related to ion and water transport functions of the proteins (White et al., 1998; Shiels et al., 2001; Kumari et al., 2013; Hu et al., 2017; Gu et al., 2019; Varadaraj and Kumari, 2019). The gene discussed is GJA8; the disease is cataract.