For instance, in a neuroendocrine tumor mouse model, targeting endothelial cells and activated tumor infiltrating macrophages (CD68+) with the LN-inducing cytokine LIGHT (TNFSF14) induces production of CCL21, TNFα, and IL1β that, overall, drive T/B cell recruitment and formation of mature TLS (Johansson-Percival et al., 2015; Johansson-Percival et al., 2017). This evidence concerns the gene TNF and neoplasm.