T helper 1 (Th1) polarized CD4+ T cells sustain inflammation and cytotoxic cell function and survival through production of IFN-γ and other cytokines (IL-15, IL-12) and are usually associated with a good prognosis in several cancer types (Bindea et al., 2013; Chraa et al., 2019). The gene discussed is CD4; the disease is cancer.