The beneficial effect of TLS seems mostly related to their qualitative cellular composition, with Th1-polarized CD4+, effector memory CD8+ T cells and mature dendritic cells associated to the best outcomes in colorectal and lung cancers (Dieu-Nosjean et al., 2008; Di Caro et al., 2014; Goc et al., 2014). This evidence concerns the gene CD8A and lung cancer.