Notably, individuals with at-risk alleles of Tcf7l2 displayed abnormal concentrations of TC, LCL, HDL, or very low-density lipoprotein (VDLL) in periphery blood (Gallardo-Blanco et al., 2017), indicating a strong association of Tcf7l2 and dyslipidemia. The gene discussed is TCF7L2; the disease is metabolic syndrome.