Among them, UCP1 and UCP2 are associated with multiple malignant tumors, including colon cancer, non-small cell lung cancer, pancreatic cancer, and BC (Ayyasamy et al., 2011a; Li et al., 2013; Pitt, 2015; Giatromanolaki et al., 2017a; Oleksiewicz et al., 2017). This evidence concerns the gene UCP1 and breast cancer.