Some studies suggest that UCPs (mainly UCP2) accelerate tumor progression by promoting aerobic glycolysis (Warburg effect) and inhibiting reactive oxygen species (ROS), thereby enhancing the resistance of cancer cells against chemotherapeutic agents (Ayyasamy et al., 2011b; Brandi et al., 2016; Giatromanolaki et al., 2017b; Yu et al., 2020). Here, UCP2 is linked to cancer.