The results showed that UCP1 was most associated with proximal substrate tubule bicarbonate reclamation, basal cell carcinoma, Renin angiotensin system, NOD like receptor signalling pathway and long term depression pathway in Normal-like, Luminal A, Luminal B, Her2-enriched and Basal-like subtypes, respectively (Supplementary Figure S3A–E). This evidence concerns the gene ERBB2 and basal cell carcinoma.