In this study, we performed a bioinformatic analysis for the functions of UCP1 and UCP2 and their prognostic significance for BC patients using data from online databases, validated the prognostic roles of UCP1 and UCP2 in BC in clinical samples collected from these patients, and analyzed the relationship between UCP1 and UCP2 and BC thermogenesis. The gene discussed is UCP2; the disease is breast cancer.