DISC1 and intervertebral disk degenerative disorder: Wang et al. (2021) showed that circARL15 played crucial roles in IDD development by sponging the miR-431-5p/DISC1 axis. Recently Guo et al. (2021) performed microarray hybridization and qRT-PCR assay to study differentially expressed circRNAs and identified that the expression of circ_0005918 was upregulated in the IDD group.