VSMC in BBA-enriched genes like CXCL5, CXCL6, PTX3, SPP1, PLOD2, SERPINE1, MT2A, LOX, and COL6A3. These genes have a high correlation to arterial inflammation, lipid metabolization, severe atherosclerosis, and collagen degradation (|log2FC| > 0.75, FDR < 0.1, p < 0.05) (Figure 2B). The gene discussed is SERPINE1; the disease is atherosclerosis.