TNF and atherosclerosis: KEGG further summarized the BBA-derived Mo/Mφ with upregulating function in lipid and atherosclerosis and IL-17, TNF, AMPK, and NF-kappa B signaling pathways, while IA-derived Mo/Mφ have more abundant cellular pathway functions in phagosome, antigen presenting, and other mild inflammation process (|log2FC| > 0.75, FDR < 0.1, p < 0.05) (Figure 3D).