As one of highly enriched miRNAs in hUC-MSC-sEVs (36–38, 62), miR-100-5p delivered by MSC-sEVs was found to protect cartilage from damage in osteoarthritis, and inhibit NLRP3 inflammasome activation and suppress cytokine release to ameliorate myocardial ischemia/reperfusion injury (63, 64). Here, NLRP3 is linked to osteoarthritis.