In this regard, irradiation can uncover or release previously hidden antigens and trigger remarkable immune-stimulatory effects, such as enhancing the expression of MHC-I on the tumor cell surface, upregulating FAS/CD95, normalizing aberrant tumor vasculature, and promoting the release of cytokines and chemokines, which can improve the infiltration of multiple immune cells into the tumor (8, 12–14). This evidence concerns the gene FAS and neoplasm.