PLD1 and cancer: We further performed in vitro validation experiments based on the integromics results, presenting that oral ceruloplasmin combined with probiotics can inhibit the expression of Spin1 and pld1 and promote Treg differentiation through elevated PS (18:0/18:1) in the IDO1/vitamin B6 and glycerophospholipid metabolic pathways.Spin1 is overexpressed in many cancers and can promote cell proliferation, transformation, metastasis and chemical or radiation resistance (49).