It is noteworthy that SPIN1 can regulate abnormal lipid metabolism by increasing triglyceride, cholesterol and lipid droplets in liver cancer cells, thus significantly promoting the proliferation of liver cancer cells (50), but there are few studies on THE differentiation of Treg by spin1 regulating lipid metabolism.Pld1 plays an important role in a variety of inflammatory and autoimmune diseases. Here, PLD1 is linked to autoimmune disease.