Cancer cells in the GG components mostly interacted with stromal cells, club cells, and macrophages via adhesion molecules such as ESAM, CADM1, CDH1, and LAMC. In addition, CD47 is specifically highly expressed in GG focal cancer cells, and the associated SIRPA is also highly expressed and correlated within many immune cells such as mature DCs, where CD47 acts as a classical immune escape molecule to block the maturation of immune cells and release immune-activating factors through the CD47–SIRPA axis (57). Here, ESAM is linked to cancer.