CD2 and cancer: In addition, compared to cancer cells in the GG components, cancer cells in the S component samples exhibited more significant potential interactions with DCs, mainly via adhesion molecules such as ICAM1 and F11R. At the same time, the adhesion molecule of CD58 that interacted with T-cell receptor CD2 was highly expressed in cancer cells, indicating higher immunogenicity in the S component samples, which activated T cells for its cytotoxicity (48).