Binding of syntenin-1 is regulated by phosphorylation of two serine residues in the C-tail of UNC93B1 and inhibition of the UNC93B1/syntenin-1 interaction or K63-ubiquitination of UNC93B1 results in enhancement of TLR7 signaling and causes autoimmunity in mice (24). The gene discussed is UNC93B1; the disease is Autoimmunity.