ANGPT2 and lung cancer: Studies have shown that the overexpression of a disintegrin and metalloproteinase 9 (ADAM9) can promote the brain metastasis of lung cancer cells, further studies have shown that ADAM9 can promote the vascular remodeling of lung cancer cells and brain metastasis by increasing the expression of vascular endothelial growth factor A (VEGFA), Ang2 and tissue plasminogen activator (PLAT) (54).