TEK and non-small cell lung carcinoma: Studies have shown that Ang2, Tie2 and Myeloid-derived suppressor cells (MDSC) are involved in the immune escape of non-small cell carcinoma, the collection of clinical data shows that the high expression of ANGPT2/TIE2 + monocytic-MDSC in non-small cell carcinoma is closely related to its poor prognosis (47).