[TIMP-2] • [IGFBP7] predicted the development of stage 2 and 3 AKI in high-risk and critically ill patients with sepsis with an AUC of 0.84. The biomarker performed similarly regardless of disease severity (SOFA score), with a sensitivity of 77.5% and specificity of 75% for severe AKI at a cut-off value of 1.0 (113). This evidence concerns the gene TIMP2 and Sepsis.