T cell vesicles retained LFA-1, PD-1, TGF-βR and FasL. They actively targeted tumor tissues through LFA-1/ICAM-1 interaction, rescued antitumor effects of CD8+ T cells by blocking PD-1 and TGF-β, and directly induced apoptosis of tumor cells via Fas/FasL axis. Here, TGFB1 is linked to neoplasm.