CD8A and graft versus host disease: On the other hand, development of acute GVHD induced by intravenous injection of either T cell-depleted bone marrow from C57BL/6 mice or CD4+ and CD8+ T cells from FVB mice was significantly greater in irradiated C57BL/6-KitW-sh/W-sh mice than in irradiated C57BL/6 wild-type mice (103).