Maier et al., using single-cell RNA sequencing in human and mouse NSCLC specimens identified a type of DCs nominated “mature DCs abundant in immunoregulatory factors” (mregDCs), which possessed both immunoregulatory genes (Cd200, Cd274, and Pdcd1lg2) and maturation genes (Cd40, Ccr7, and Il12b). Here, CD274 is linked to non-small cell lung carcinoma.