The release of tumor recruitment–soluble factors, such as CXCL8, CXCL1, CXCL5, CXCL7, IL-6, and IL-1β, enhances immunosuppressive neutrophil chemotaxis through CXCR2 sensing, found to be highly expressed in NSCLC patients (39, 40). This evidence concerns the gene IL1B and neoplasm.