A number of PD-1, PD-L1, and CTLA-4 inhibitors, including pembrolizumab (196), nivolumab (197), atezolizumab (198), durvalumab (199), avelumab (200), and ipilimumab (201), have been approved for the treatment of advanced NSCLC. The gene discussed is CTLA4; the disease is non-small cell lung carcinoma.