Subsequently, neutrophil mobilization to pancreatic islets, most likely occurs via platelet-derived proplatelet binding protein (PPBP) which undergoes cleavage to form CXCL7/NAP2 (a neutrophil -activating and - recruiting chemokine) (53–55) and has been found elevated in T1D human blood by serum proteome analysis (56). This evidence concerns the gene PPBP and type 1 diabetes mellitus.