Studies have also shown that low doses of 2-DG inhibition of glucose metabolism combined with a MEK inhibitor induces apoptosis in krasg12d-driven pancreatic ductal adenocarcinoma cells, and experiments also show that this combination treatment inhibited the growth of xenograft pancreatic ductal adenocarcinoma and prolonged total survival (103). This evidence concerns the gene MAP2K7 and pancreatic ductal adenocarcinoma.