HIF1A and neoplasm: In addition, it has been demonstrated that HIF-1α-stabilizing long noncoding RNA (HISLA) blocks PHD2 and HIF-1α interaction and thereby suppresses HIF-1α hydroxylation and degradation, while HIF-1α promotes aerobic glycolytic processes in tumor cells and released lactate upregulates HISLA, in macrophages that constitutes a feedforward loop between TAMs and tumor cells (46).