1.Binds Gal-9 to induce apoptosis in Th1 and CD8 TIL.   2. TIM-3 blockade enhance tumor antigen-specific T-cell proliferation and activity.3.TIM-3 interacted with HMGB1 to suppress antitumor immunity mediated by nucleic acids. Here, HAVCR2 is linked to neoplasm.