In a recent study of 424 COVID-19 positive patients (392 Saudi, 32 non-Saudi), the KIR2DS4 gene was associated with the highest risk of severe COVID-19 infection (OR 8.48, p= 0.0084) followed by KIR3DL1 (OR 7.61, p=0.0192) (34). The gene discussed is KIR3DL1; the disease is COVID-19.